Treatment for invasive and cutaneous aspergillosis: When possible, immunosuppressive medications should be discontinued or decreased. People with severe cases of aspergillosis may need surgery. Expert guidance is needed for infections not responding to treatment, including antifungal-resistant infections This document constitutes the guidelines of the Infectious Diseases Society of America (IDSA) for treatment of aspergillosis and replaces the practice guidelines for Aspergillus published in 2008 gillosis(IPA),Aspergillus sinusitis, disseminated aspergillosis, and several types of single-organ IA. Summarized below are the 2016 recommendations for the management of aspergillosis. Due to the guidelines' relevance to pediatrics, the guideline has been reviewed and endorsed by the Pediatric Infectious Diseases Society (PIDS). The pane NatioNal GuideliNes for the PreveNtioN of Nosocomial asPerGillosis Foreword The first version of the National Aspergillosis Prevention Guidelines were well received and since 2002 have helped to guide infection control practice in healthcare facilities where there is an ongoing risk of nosocomial aspergillosis
In the environment (and on culture plates) Aspergillus species grow in the vegetative state that is composed of long filamentous structures (hyphae) attached to the substrate upon which the fungus is feeding AND as aerial hyphae, which including a distinctive appearance that resembles an aspergillum (an instrument used for sprinkling holy water in Roman Catholic and Anglican traditions) with associated spores (called conidia) [ Fig] Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus The recommendations in this guide are meant to serve as treatment guidelines for use at Michigan Medicine facilities. If you are an individual experiencing a medical emergency, call 911 immediately. These guidelines should not replace a provider's professional medical advice based on clinical judgment, or be used in lieu of a
IDSA Guidelines for Aspergillosis • CID 2008:46 (1 February) • 327 IDSA GUIDELINES Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America Thomas J. Walsh,1,a Elias J. Anaissie,2 David W. Denning,13 Raoul Herbrecht,14 Dimitrios P. Kontoyiannis, The guideline covers the diagnosis of invasive pulmonary aspergillosis, invasive candidiasis and the three most common endemic mycoses: blastomycosis, coccidioidomycosis and histoplasmosis. Effective treatment of patients with these infections depends on rapid, accurate diagnosis of the infection and on timely treatment Allergic bronchopulmonary aspergillosis is a hypersensitivity reaction to bronchial colonisation by mould, typically affecting patients with asthma or cystic fibrosis. Exposure of atopic people to fungal spore elements results in the formation of immunoglobulin E and immunoglobulin G antibodies...
Guidelines Summary Guidelines on the management of aspergillosis by the Infectious Diseases Society of America are as follows [ 56, 57] : Submit tissue and fluid specimens for histopathologic,.. The guidelines address 98 clinical questions that cover the three main presentations of Aspergillus infection, invasive, chronic or saprophytic, and allergic aspergillosis. The executive summary succinctly lists these 98 questions, while the body of the document elaborates the evidence base for each recommendation
Available guidelines for aspergillosis management recommend diagnostic procedures such as respiratory culture and galactomannan index of BAL samples (references 60,62 in Appendix). However, these procedures have a high risk for aerosolization; safety precautions should be used when handling samples from COVID-19 patients (references 63 , 64 in. This document constitutes the guidelines of the Infectious Diseases Society of America for treatment of aspergillosis and replaces the practice guidelines for Aspergillus published in 2000 . The objective of these guidelines is to summarize the current evidence for treatment of different forms of aspergillosis The updated guidelines focus on the diagnosis and treatment of the major forms of aspergillosis: allergic, chronic and invasive, the latter which kills 40% to 80% of those with widespread infection. While generally harmless, aspergillus can cause an allergic reaction or chronic lung problems in some people and serious, invasive disease in. Aspergillus Management EOP53 (Version 1 updated 2nd February 2000) • Aspergillus website ~ www.aspergillus.man.ac.uk These guidelines are mainly consensus based, with evidence used where available. A consultation document containing draft guidelines was circulated in April 2001 t Aspergillus guidelines now recommend the use of either voriconazole or isavuconazole for first-line treatment of invasive aspergillosis, while first-line combination antifungal therapy is not routinely recommended. As only few new data were published since the last ECIL guidelines, no major changes were made to mucormycosis recommendations
Antifungal Guideline for Invasive Fungal Infections in Adults, August 2019. Version 2.0 Page 10 ASPERGILLOSIS: TREATMENT OF ACUTE INVASIVE ASPERGILLOSIS Surgical interventions crucial in management of sinonasal, paranasal granuloma, osteomyelitis, cerebral and endocarditis. 1st line: Voriconazole 6 mg/kg IV every 12 hours for 2 doses then 4mg/kg I . This section provides detailed protocols on the treatment of those infections and details of their most prominent references. NOTE Here are published guidelines for the diagnosis and treatment of Chronic Pulmonary Aspergillosis (2019) There are also details of all the antifungal drugs currently in use and.
Subacute invasive pulmonary aspergillosis (formerly called chronic necrotising pulmonary aspergillosis) is a more rapidly progressive infection (<3 months) usually found in moderately immunocompromised patients, which should be managed as invasive aspergillosis. Few clinical guidelines have been previously proposed for either diagnosis or. The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host. Invasive aspergillosis develops in severely immunocompromised patients, including those with neutropenia, and increasingly in the non-neutropenic host, including lung transplant recipients, the critically ill patients and patients on steroids Aspergillus is a mould which may lead to a variety of infectious, allergic diseases depending on the host's immune status or pulmonary structure. Invasive pulmonary aspergillosis occurs primarily in patients with severe immunodeficiency. The significance of this infection has dramatically increased with growing numbers of patients with impaired immune state associated with the management of. Until histopathological evidence of COVID-19-associated pulmonary aspergillosis is obtained, we believe that patients with COVID-19 who are critically ill with evidence for Aspergillus spp in bronchoalveolar lavage or serum should receive antifungal therapy according to national and international guidelines. Panel
Filamentous fungi of the Aspergillus species are ubiquitously found as soil inhabitants. Inhalation of the aerosolised conidia (spores) causes the infection. The clinical spectrum varies from colonisation, allergy (e.g., allergic bronchopulmonary aspergillosis), asthma, or aspergilloma (fungal ball) to invasive disease, depending on host immune impairment Aspergillus Guideline: Chronic Pulmonary Aspergillosis Joint ESCMID and ERS guidelines 2 David Denning (ESCMID) George Dimopoulos (ERS) Christophe Lange (ERS) Jacques Cadranel (ERS) Francoise Ader (ESCMID) Arunaloke Chakrabarti (ESCMID) Andrew Ullman (ESCMID) Stijn Blot (ERS) Catherine Beigelman-Aubry (ESCMID Aspergillus Otomycosis. Otomycosis is subacute or chronic superficial fungal infection of the external auditory canal and auricle. It is the most frequently encountered fungal infection in ear, nose and throat clinics. The organisms responsible for this clinical entity are usually environmental saprotrophic fungi especially A. niger INTRODUCTION. Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction that occurs in response to colonization of the airways with Aspergillus fumigatus and almost exclusively in patients with asthma or cystic fibrosis (CF) .In some cases, repeated episodes of bronchial obstruction, inflammation, and mucoid impaction can lead to bronchiectasis, fibrosis, and.
The following table from Dr. Spurgeon's talk is a summary of guidelines from three studies cited by Dr. Spurgeon: Table: Asp/Pen levels considered as indicative of a moldy environment by three independent studies: Baxter data: Asp/Pen ≥ 950 spores/m 3. Rimkus data: Asp/Pen ≥1,000 spores/m 3. Spurgeon data: Asp/Pen ≥ 1,000‐1,100. Aspergillus colonization was established by positive Aspergillus detection from sputum culture for 2 or more times (≥2 times in the absence of compliance with the diagnostic criteria for CPA, allergic bronchopulmonary aspergillosis, invasive pulmonary aspergillosis and/or other diseases) guidelines that differ from postoperative endophthalmitis after cataract surgery. Exogenous endophthalmitis may present in an acute, virulent form, or a more chronic, late endophthalmitis. particularly Aspergillus spp).The etiology of postoperative endophthalmitis may vary with regions of the world, as depicted in Table 6 The guidelines recommend that both surgery and either systemic voriconazole or a lipid formulation of amphotericin B be used in invasive Aspergillus fungal sinusitis, but surgical removal alone. The performance of antibody detection, antigen detection, andAspergillus genus-specific PCR for diagnosingAspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with proven infection caused by Aspergillus fumigatus. Immunoglobulin G antibodies directed against Aspergilluswere not detected by enzyme-linked immunosorbent assay in CSF or.
Aspergillosis is an infection caused by a type of mold (fungus). The illnesses resulting from aspergillosis infection usually affect the respiratory system, but their signs and severity vary greatly. The mold that triggers the illnesses, aspergillus, is everywhere — indoors and outdoors Despite the diagnostic tools at our disposal to detect aspergillosis, the clinical diagnosis of aspergillosis is still difficult and often relies on clinical guidelines, such as the EORTC/MSG and AspICU diagnostic criteria. 3, 4 The EORTC/MSG guidelines were created for the classical immunocompromised host for aspergillosis with classifications. Aspergillus Niger. What do canned fruit, shampoo, and blood preservation have in common? Yup, you guessed it. They all rely on citric acid produced by Aspergillus Niger!. Aspergillus Niger has been used for citric acid production for over 100 years. Citric acid is used as preservative and flavouring agent in a wide range of commonly used products
Aspergillus is a saprophytic fungus that helps remove environmental carbon and nitrogen from the earth's atmosphere. Aspergillus is most commonly found in the soil around us, where it thrives on naturally occurring organic debris. While Aspergillus predominantly grows underground, its spores propagate rapidly in the air with each fungus capable of producing thousands of conidia These updated AST‐IDCOP guidelines provide information on epidemiology, diagnosis, and management of Aspergillus after organ transplantation. Aspergillus is the most common invasive mold infection in solid‐organ transplant (SOT) recipients, and it is the most common invasive fungal infection among lung transplant recipients. Time from. Allergic bronchopulmonary aspergillosis (ABPA) is an allergic or hypersensitive reaction to a fungus known as Aspergillus fumigatus. This is a fungi found in the soil. Although most of us are frequently exposed to Aspergillus, a reaction to it is rare in people with normal immune systems. However, in certain people, the immune system overreacts. Background. Aspergillosis is an infection of tissues or cavities caused by fungi of the genus Aspergillus.Aspergillosis of the central nervous system is a rare disease with a high mortality that occurs more frequently in immunocompromised patients and is not often observed in immunocompetent patients
These updated AST-IDCOP guidelines provide information on epidemiology, diagnosis, and management of Aspergillus after organ transplantation. Aspergillus is the most common invasive mold infection in solid-organ transplant (SOT) recipients, and it is the most common invasive fungal infection among lung transplant recipients. Time from transplant to diagnosis of invasive aspergillosis (IA) is. Aspergillus is a mould commonly found in many indoor environments. Demolition or refurbishment work, particularly of older buildings, can release fungal spores. People with damaged lungs or a weakened immune system can get a number of diseases (called Aspergillosis or farmer's lung) if they inhale these spores Advanced chronic obstructive pulmonary disease (COPD) often leads to hospitalisation and invasive aspergillosis (IA) is a serious complication. Aspergillus sensitisation may worsen symptoms in COPD. We identified published papers between January 2000 and May 2019 with > 50 subjects and GOLD criteria for grade II, III or IV (FEV1/FVC < 70% and FEV1 < 80%) using standardised criteria in multiple.
The UK National Aspergillosis Centre (NAC) is based at our renowned North West Lung Centre, Wythenshawe Hospital. It is part of the Infectious Diseases service and provides expert fungal infection management. In 2009 NAC was commissioned by the Department of Health to provide long term care for patients with chronic pulmonary aspergillosis (CPA) Aspergillus , a genus of spore forming fungi found worldwide, affects the respiratory tract in many ways [1, 2]. The spores of this ubiquitous mould are dispersed by wind in the atmosphere and inhalation is the primary route of access in almost all forms of aspergillosis. The spectrum of Aspergillus -associated respiratory disorders comprises three well defined clinical categories (table 1. testing of all Aspergillus spp, if treatment is to be given. In this Review, we provide information to improve understanding of the importance of antigen detection for cryptococcal disease and invasive aspergillosis, the use of molecular (PCR) diagnostics for aspergillosis, and the crucial role of antibody detection for chronic and allergi Aspergillosis. Aspergillosis most commonly affects the respiratory tract but in severely immunocompromised patients, invasive forms can affect the heart, brain, and skin. Voriconazole is the treatment of choice for aspergillosis; liposomal amphotericin B is an alternative first-line treatment when voriconazole cannot be used
-In general, recommended as primary therapy for invasive syndromes of Aspergillus-Current guidelines should be consulted for additional information. Usual Adult Dose for Esophageal Candidiasis. Less than 40 kg: 100 mg orally every 12 hours At least 40 kg: 200 mg orally every 12 hour Aspergillus is a mold commonly found in environmental sources such as soil, dust, building material, decomposing plant matter, and water. 1 As an infectious pathogen, it primarily causes invasive pulmonary infection, but other infections are possible and may occur as either primary infection (eg, sinusitis or cutaneous) or by hematogenous spread (eg, cardiovascular or central nervous. GUIDELINES FOR TREATMENT OF INVASIVE ASPERGILLOSIS AND As a result of ongoing research, practice guidelines may from time to time change. The authors of these guidelines have made all attempts to ensure the accuracy based on current information, however, due to ongoing research, users of these guidelines are strongly encouraged to. ♦ Aspergillus is a mold that is in the air we breathe, particularly in air conditioning units and flood-damaged areas.. ♦ In addition to the invasive form, aspergillus can cause chronic and allergic forms of disease. The improved use of diagnostic tools has enhanced the ability to identify the infection early, the guidelines note
Guidelines from the Infectious Diseases Society of America (IDSA) for treatment of aspergillosis and replaces that replaces the practice guidelines for Aspergillus published in 2008. The recommendations are published in the journal Clinical Infectious Diseases. Key Recommendations It is important to emphasize that guidelines by both of these panels are intended to supplement, not supplant, clinical judgment in the care of individual patients. The NCCN also states that the best management of any cancer patients occurs on clinical trials. H&O What do the guidelines recommend for prevention of invasive aspergillosis in AML The Infectious Diseases Society of America has released new clinical practice guidelines for the diagnosis and management of aspergillosis that advocate the use of better-tolerated antifungal.
Aspergillosis is a fungal infection caused by Aspergillus, which comprises a large group of ubiquitous mold species (spp) most frequently found in decomposing vegetation. 1 Aspergillosis, which is most commonly observed in immunocompromised persons, is a significant cause of morbidity and mortality in this population, with mortality rates as. Guidelines for Validation of Microbiological Methods for Food and Environmental Surfaces [Official Methods of Analysis of AOAC INTERNATIONAL (2019) 21st Ed., AOAC INTERNATIONAL, Rockville, MD, USA]; or ISO 16140-2:2016 At the time of the publication, no national reference method exists for the confirmation of Aspergillus from cannabis products • 5 cases of Aspergillus infection in patients on a burn unit, dialysis unit and oncology unit • Air intake vents not covered during demolition American health consultants. Aspergillosis: a deadly dust may be in the wind during renovations. Hosp Infect Control 1995;22(10):125-26 Failure to Protec City Department of Health. This document is still available from EMLab P&K. The guidelines are being updated and the revised one should be available in 2000. 8. Identify problem fungi, such as Aspergillus fumigatus, A. flavus, A. niger, or Fusarium moniliforme (syn. F. sporotrichoides)
Welcome. We are excited to once again assemble many of the leading clinicians and scientists from around the world for the 9th Advances Against Aspergillosis and Mucormycosis conference, to take place in Lugano, Switzerland from 27th to 29th February 2020.This conference has now clearly established itself as the premier forum for detailed and dedicated discussion of all aspects of Aspergillus. Invasive aspergillosis (IA) is a severe life-threatening infection with challenges in therapy. The aim was to evaluate the level of evidence (LOE) supporting recommendations in clinical practice guidelines (CPGs) of IA and changes over time. Search on CPG on IA released between 2000 and 2019 was done. Last versions were evaluated and compared with previous versions Nevertheless, sampling may provide useful information and you should research some general guidelines for interpreting results. In this post, I want to highlight two documents that are freely available on the website of Environmental Analysis Associates, Inc. (EAA), a commercial laboratory in San Diego, CA Aspergillosis. Edited May, 2017. The Aspergillosis guidelines were first published in the J Feline Med Surg 2013, 15: 605-610 by Katrin Hartmann et al. The present guidelines were updated by Katrin Hartmann and Vanessa Barrs (University of Sidney). Synopsis . Aspergillosis is a sporadic mycosis that occurs worldwide in mammals and birds Aspergillus fl avus and Aspergillus niger also contribute to the total burden of pulmonary aspergillosis. When inhaled, spores deposit by sedimentation in distal airways and alveolar spaces. In healthy hosts, spores are elimi-nated by mucociliary clearance and immune defenses. Germination is the conversion of dormant spores int
There are hundreds of different species of Aspergillus, but according to the Center for Disease Control (CDC), only 40 of them can affect human beings. Among them, Aspergillus fumigatus is the most common and most virulent species. Aspergillus fumigatus is a saprotrophic fungus with cosmopolitan distribution. In nature it can typically be found. Guidelines for prophylaxis and empirical therapy forinvasive aspergillosis in neutropenic hosts have recently been published  and will not be discussed here
Patterson TF, Thompson GR III, Denning DW, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clinical. Patterson TF, Thompson GR III, Denning DW, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis
Aspergillus. Aspergillus is a very large genus containing about 250 species, which are currently classified into seven subgenera that are in turn subdivided into several sections comprised of related species (Raper and Fennell 1965, Gams et al.1985, Geiser et al. 2007).. Traditionally, clinical microbiology laboratories have relied heavily on morphology-based identification methods to. According to the guidelines of Infectious Diseases Society of America (IDSA) for treatment of aspergillosis, the recommendation for the diagnosis of IA should be based on tissue and fluid specimens submitted in adequate quantities for simultaneous histopathologic/cytologic and culture examination, until molecular tools are more widely used in. Practice Guidelines for Diseases Caused by Aspergillus David A. Stevens,1'2'9a Virginia L. Kan,3 9 Marc A. Judson,4'9 Vicki A. Morrison,5'12 Stephen Dummer,6'9 David W. Denning,13 John E. Bennett,7'9 Thomas J. Walsh,8'9 Thomas F. Patterson,9'10 and George A. Pankey9' From the 'Santa Clara Valley Medical Center, San Jose A literature search of PubMed was performed (January 2002 to April 2021) using the following search terms: allergic bronchopulmonary aspergillosis, aspergillus-related lung disease, cystic fibrosis. Manufacturer prescribing information, clinical practice guidelines, and data from ClinicalTrials.gov were incorporated in the reviewed data Clinical practice guidelines for the treatment of invasive Aspergillus infections in adults in the Middle East region: Expert panel recommendations By Hail Al-abdely , Tariq al-Musawi , Abdulahakeem Althaqafi , and Jameela Salma
Allergic bronchopulmonary aspergillosis (ABPA) is a complex pulmonary disorder characterized by a hypersensitivity reaction to Aspergillus fumigatus, and almost always seen in patients with cystic fibrosis (CF) and asthma. Fungal hyphae leads to an ongoing inflammation in the airways that may result in bronchiectasis, fibrosis, and eventually loss of lung function Infection by these Aspergillus fungi causes the internal tissues of the cavity of fresh figs to turn bright yellow (A. ochraceus and A. melleus), bright green (A. flavus), brown green (A. tamarii), or dark green to olive color (A. parasiticus). Eventually the tissues become powdery from the production of masses of spores. Parts of the cavity (usually close to the ostiole - eye of fig) or the. Ullmann A et al; Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline, Clinical Microbiology and Infectious Diseases, 2018. Kamalaporn H, Leung K, Nagel M, et al ; Aerosolized liposomal Amphotericin B: a potential prophylaxis of invasive pulmonary aspergillosis in immunocompromised patients PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. NAME: Aspergillus spp. SYNONYM OR CROSS REFERENCE: Aspergillosis, farmer's lung, A. fumigatus, A. flavus, A. niger, A. nidulans, A. terreus Footnote 1. CHARACTERISTICS: The genus Aspergillus belongs to the class Euascomycetes of the Phylum Ascomycota Footnote 1.They consist of anamorphic (asexual) species with. Aspergillus is a fungus with spores that can be inhaled and deposited into airways. The fungus can produce toxic and allergenic exoproducts and cause a number of problems in Cystic Fibrosis (CF). Generally the advice is to avoid environments where high levels of fungus can occur; damp straw such as in horse stables, building sites, and exposure.
Certain species of a common fungus called Aspergillus can infect the nasal cavity and sinuses of cats and can even become disseminated to different areas of the body. Cats affected by exposure to this fungus are usually immunosuppressed. Diagnosis of either form, the nasal form or disseminated form, can be difficult, usually requiring X-rays or more advanced imaging such as MRI or CT, as well. Reported modes of acquisition of vertebral aspergillosis in immunocompetent patients No. (%) of Mode of acquisition cases (n 5 21) Case number(s) Species Trauma 1 (5) 7 Aspergillus fumigatus, Aspergillus niger Spinal surgery/procedure 5 (24) 2, 6, 10, 14, 16 A. fumigatus Contiguous spread 2 (10) 9, 17 A. fumigatus Hematogenous 11 (52) 1, 3, 4. Investigators in Spain and the United States have added 20 new case reports to mounting evidence that patients with coronavirus disease 2019 (COVID-19) are vulnerable to developing pulmonary aspergillosis. Authors of the case series noted that increased physician awareness in recent years of an association between severe influenza and the fungal infection may have led to more rapid recognition. Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. This fungus grows on dead leaves, stored grain, compost piles, or other decaying vegetation. The Aspergillus species includes more than 150 types of mold that occur widely in the indoor and outdoor environment. Aspergillus is commonly found as a lacy. Aspergillus guideline spanish_ver(1) 1. GUI´AS DE IDSA • CID 2008:46 (1 February) • T1 G U I´ A S D E I D S A Tratamiento de la Aspergilosis: Guı´as para la pra´ctica clı´nica de la Sociedad de Enfermedades Infecciosas de los Estados Unidos de Ame´rica (IDSA) Thomas J. Walsh,1,a Elias J. Anaissie,2 David W. Denning,13 Raoul Herbrecht,14 Dimitrios P. Kontoyiannis,3 Kieren A. Marr,5.
There are a number of different manifestations of pulmonary aspergillosis. This study aims to review the radiology, presentation, and histological features of lung nodules caused by Aspergillus spp. Patients were identified from a cohort attending our specialist Chronic Pulmonary Aspergillosis clinic. Patients with cavitating lung lesions, with or without fibrosis and those with aspergillomas. The EQUAL Aspergillosis Score 2018 is a 16-item scoring-tool, derived from current guidelines and management path publications, to inform about quality of clinical invasive pulmonary aspergillosis care.3, 6, 7, 10 From these documents we weighed the strongest recommendations on diagnosis, treatment, and follow-up Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response of the immune system (a hypersensitivity response) to the fungus Aspergillus (most commonly Aspergillus fumigatus).It occurs most often in people with asthma or cystic fibrosis. Aspergillus spores are ubiquitous in soil and are commonly found in the sputum of healthy individuals TREATMENT Early initiation of antifungal therapy in patients with strongly suspected invasive aspergillosis is warranted while a diagnostic evaluation is conducted  For primary treatment of invasive pulmonary aspergillosis, IV or oral voriconazole is recommended for most patients   IDSA Guidelines Clin Infect Dis. (2008) 46 (3):327-360 features of the guideline are highlighted in a short article published to accompany the full guideline.2 The following is a summary of the recommendations and good prac-tice points and includes all figures 1-5 and tables 1-7. The sections referred to in the summary refer to the full guideline. Table 1 provides a summary of overall management