. People with rapidly progressive glomerulonephritis may present with a nephritic syndrome. In management, steroid therapy is sometimes used, although the prognosis remains poor When rapidly progressive glomerulonephritis ( Engl. Rapidly progressive glomerulonephritis, shortly RPGN) is it is an intermittently occurring extracapillary glomerulonephritis associated with a rapid loss of renal function associated. If left untreated, kidney failure can occur within weeks to months . Further synonyms for this disease are rapidly progressive glomerulonephritis and crescentic. Category:Rapidly progressive glomerulonephritis. Microfotografia d'una glomerulonefritis ràpidament progressiva en un pacient amb MPO-ANCA positiu. Mostra la hipercel·lularitat inflamatòria en semilluna a la part superior esquerra del glomèrul en la imatge. Tinció d'HE Glomerular. Glomerulonephritis. IgA nephropathy (Berger disease) Lupus nephritis. Hereditary nephritis (Alport syndrome) Toxemia of pregnancy. Serum sickness. Erythema multiforme. Nonglomerular
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of glomerular disease in the urinalysis and by progressive loss of renal function over a comparatively short period of time (days to weeks). It is most commonly characterized morphologically by extensive crescent formation Rapidly progressive glomerulonephritis, also known as crescentic GN, is characterised by a rapid, progressive deterioration in kidney function. People with rapidly progressive glomerulonephritis may present with a nephritic syndrome Hurtigt fremadskridende glomerulonephritis ( RPGN) er et syndrom af nyren, som er karakteriseret ved et hurtigt tab af nyrefunktion, (normalt en 50% nedgang i den glomerulære filtrationshastighed (GFR) inden for 3 måneder) med glomerulær halvmånedannelse set i mindst 50 % eller 75% af glomeruli set på nyrebiopsier. Hvis den ikke behandles, udvikler den sig hurtigt til akut nyresvigt og. rapidly progressive glomerulonephritis RPGN, or crescentic glomerulonephritis, is a severe form of glomerulonephritis that leads to end-stage renal disease invariably in a matter of weeks. Patients present with acute nephritis picture associated with progressive loss of renal function Glomerulonefrita rapid progresivă ( RPGN) este un sindrom al rinichiului care se caracterizează printr-o pierdere rapidă a funcției renale (de obicei o scădere cu 50% a ratei de filtrare glomerulară (GFR) în decurs de 3 luni) cu formare a semilunei glomerulare observată în cel puțin 50 % sau 75% din glomeruli observați la biopsiile renale. . Dacă nu este tratată, aceasta.
Pauci-immune crescentic GN is the most frequent cause of rapidly progressive GN and the pulmonary-renal syndrome. The differential diagnosis in crescentic pauci-immune GN is: Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic crescentic GN Nopeasti etenevä munuaiskerästulehdus ( RPGN) on oireyhtymä ja munuaisten, jolle on tunnusomaista nopea munuaisten toiminnan menetys, (yleensä 50% lasku glomerulusfiltraation (GFR) kuluessa 3 kuukausi) glomerulusten puolikuun muodostuminen nähdään vähintään 50 % tai 75% munuaisbiopsiassa havaituista glomeruloista. Hoitamattomana se etenee nopeasti akuutiksi munuaisten.
種類. 急性糸球体腎炎（Acute glomerulonephritis）; 急速進行性腎炎症候群（Rapidly progressive glomerulonephritis）; 慢性糸球体腎炎（Chronic glomerulonephritis）; 急性糸球体腎炎. 急性糸球体腎炎（英語: Acute glomerulonephritis; AGN ）は、その90%が連鎖球菌感染に続発していることから、溶連菌感染後急性糸球体腎炎. .. This inflammation ultimately causes a proliferation of cells in the Bowman's space, which forms a crescent shape and this change leads to renal failure relatively quickly—within weeks to months
Acute glomerulonephritis and rapidly progressive glomerulonephritis. John R. Sedor, in Nephrology Secrets (Fourth Edition), 2019. 1. What is the syndrome of acute glomerulonephritis? Acute glomerulonephritis is an acute kidney injury (AKI) syndrome characterized by the sudden onset of edema and new-onset or worsening hypertension. Urinalysis. Rapidly progressive glomerulonephritis can be of 3 types : Type I (Anti-GBM antibody) Type II (Immune complex) Type III (pauci-immune) Goodpasture syndrome is an example of Type I rapidly progressive glomerulonephritis. IgA nephropathy and Lupus nephritis are examples of type II. Microscopic polyangiitis is classified as Type III (pauci-immune) Hematuria, persistent or recurrent, macroscopic or asymptomatic microscopic. Gross hematuria initially begins a few days after febrile illness, thus mimicking acute postinfectious glomerulonephritis. Mild proteinuria. +/- flank pain, fever during acute episodes. Usually slowly progressive, but rapidly progressive glomerulonephritis manifests. Fibrillary GN is a disease which affects the millions of filtering units that make up the kidney. These filtering units are called glomeruli. Each individual glomerulus is composed of multiple layers of straining material. In this condition, the body produces a large volume of unusual proteins. These proteins enter the filters Plasmapheresis for rapidly progressive glomerulonephritis: the mystique of dramatic intervention . A fourth mechanism described here is based on the observation that the IgG fraction of the serum of certain patients with glomerulonephritis contains a protein termed C4 nephritic factor (NFc), which prevents the intrinsic decay of C4b2a
Bei der rasch progressiven Glomerulonephritis (englisch rapidly progressive glomerulonephritis, kurz RPGN) handelt es sich um eine schubweise auftretende extrakapilläre Glomerulonephritis, die mit einem raschen Verlust der Nierenfunktion einhergeht. Unbehandelt kann es innerhalb von Wochen bis Monaten zum Nierenversagen kommen. Weitere Synonyme für diese Erkrankung sind rasch progrediente. dependent on presentation - nasal lesion: cocaine use; other causes of pulmonary hemorrhage; other causes of rapidly progressive glomerulonephritis Granulomatosis with polyangiitis , abbreviated GPA , is a type of vasculitis that typically afflicts the lungs and kidneys Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that, if left untreated, rapidly progresses into acute renal failure and death within months. In 50% of cases, RPGN is associated with an underlying disease such as Goodpasture syndrome, systemic lupus erythematosus, or Wegener granulomatosis; the remaining cases are idiopathic.. Regardless of the underlying cause, RPGN.
200 Chapter 9: Infection-related glomerulonephritis 209 Chapter 10: Immunoglobulin A nephropathy 218 Chapter 11: Henoch-Scho¨nlein purpura nephritis 221 Chapter 12: Lupus nephritis 233 Chapter 13: Pauci-immune focal and segmental necrotizing glomerulonephritis 240 Chapter 14: Anti-glomerular basement membrane antibody glomerulonephritis • Rapidly progressive glomerulonephritis (RPGN): proteinuria, hematuria and renal failure developing over days to a week. • Chronic GN: proteinuria, hypertension, renal failure and smooth contracted kidneys on ultrasonography (USG) examination
Introduction. Acute poststreptococcal glomerulonephritis (APSGN) is the prototype of post-infectious glomerulonephritis and is associated with a previous skin or throat infection by group A streptococcus (Streptococcus pyogenes), or occasionally groups C or G streptococcus.According to Becker and Murphy (Becker & Murphy, 1968), the development of dark and scanty urine was a feared complication. ACUTE GLOMERULONEPHRITIS (AGN) Posted on April 7, 2012 by Blue Star. A 6-year-old male developed an upper respiratory tract infection followed by facial edema with dark-colored urine after 2 weeks. Upon examination, his blood pressure was at 120/80 mmHg. There were hyperpigmented lesions noted on the lower extremities were probably due to. Medical conditions similar to or like Rapidly progressive glomerulonephritis Syndrome of the kidney that is characterized by a rapid loss of kidney function, (usually a 50% decline in the glomerular filtration rate (GFR) within 3 months) with glomerular crescent formation seen in at least 50% or 75% of glomeruli seen on kidney biopsies 急速進行性腎炎症候群. 急速進行性糸球体腎炎（英語: Rapidly progressive glomerulonephritis; RPGN ）とはWHOにより、『急性あるいは潜在性に発症する肉眼的血尿、蛋白尿、貧血、急速に進行する腎不全症候群』と定義されており、日本では難病疾患に指定されている。 日本では「腎炎を示す尿所見を伴い. Baldwin DS. Chronic glomerulonephritis: nonimmunologic mechanisms of progressive glomerular damage. Kidney Int 1982; 21:109. Lien JW, Mathew TH, Meadows R. Acute post-streptococcal glomerulonephritis in adults: a long-term study. Q J Med 1979; 48:99
Acute post streptococcal glomerulonephritis can also progress to rapidly progressive glomerulonephritis which is defined as''a syndrome that progresses rapidly within a few weeks or months to renal failure and is accompanied by urinary findings of nephritis.'' The clinical concept of rapidly progressive glomerulonephritis includes various renal. N01.4 Rapidly progressive nephritic syndrome with diffuse endocapillary proliferative glomerulonephritis N01.5 Rapidly progressive nephritic syndrome with diffuse mesangiocapillary glomerulonephritis Rapidly progressive nephritic syndrome with membranoproliferative glomerulonephritis, types 1 and 3, or NOS N01.6 Rapidly progressive nephritic.
Nearly all forms of acute glomerulonephritis have a tendency to progress to chronic glomerulonephritis. The condition is characterized by irreversible and progressive glomerular and tubulointerstitial fibrosis, ultimately leading to a reduction in the glomerular filtration rate (GFR) and retention of uremic toxins 막성사구체신염(membranous glomerulonephritis) - 비증식성(nonproliferative) 사구체신염(GN)의 질병. 주로 신증후군적인 증상이 보여지게 된다. (rapidly progressive glomerulonephritis)으로 발전하게 되며, 이는 급속한 신장기능장애와 신생검시 crescent formation이 나타나는 질병이다 Pathology (from Greek pathos, feeling, pain, suffering; and logos, study of; see also -ology) is the study of the processes underlying disease and other forms of illness, harmful abnormality, or dysfunction.Within biology but also a branch of medicine, it means specifically the study and diagnosis of the structural and functional changes in molecules, cells, tissues and organs that underlie.
Rapidly progressive glomerulonephritis. Urinary cast. Urinary casts are microscopic cylindrical structures produced by the kidney and present in the urine in certain disease states. They form in the distal convoluted tubule and collecting ducts of nephrons, then dislodge and pass into the urine, where they can be detected by microscopy.. Glomerulonephritis, also known as glomerular nephritis, abbreviated GN', is a primary or secondary immune-mediated renal disease characterized by inflammation of the glomeruli, or small blood vessels in the kidneys.It may present with isolated hematuria and/or proteinuria (blood resp. protein in the urine); or as a nephrotic syndrome, a nephritic syndrome, acute renal failure, or chronic renal. Common examples include post-streptococcal glomerulonephritis (GN), membranoproliferative GN, Henoch-Schönlein purpura (HSP), systemic lupus erythematosus (SLE), some forms of rapidly progressive glomerulonephritis (RPGN), IgA nephropathy, hemolytic uremic syndrome (HUS) and various vasculitides
Glomerulonephritis ( GN ) เป็นคำที่ใช้เรียกโรค ไต หลายชนิด (โดยปกติจะมีผลต่อไตทั้งสองข้าง) โรคหลายชนิดมีลักษณะของ การอักเสบ อย่างใดอย่างหนึ่งใน glomeruli หรือเส้น. glomerulonephritis definition: 1. a kidney disease in which the glomeruli (= tiny blood vessels that remove waste products from. Learn more Diabetes insipidus (DI) (Greek διαβαίνειν diabainein - to pass through and Latin insipidus - without taste) is a condition characterized by excretion of large amounts of severely diluted urine, which cannot be reduced when fluid intake is reduced.It denotes inability of the kidney to concentrate urine. DI is caused by a deficiency of antidiuretic hormone (ADH), also known as. Less than 10% present with either nephrotic syndrome or acute rapidly progressive glomerulonephritis. Acute or chronic renal failure may develop. Renal biopsy is required for definitive diagnosis. Light microscopy shows focal or diffuse mesangial proliferation and extracellular matrix expansion Rapidly progressive glomerulonephritis was suspected despite the biopsy findings, and circulating ANCA was measured (this test has been clinically available since 1998 in Japan). Elevation of the MPO-ANCA titer (168 EU) was found, along with an altered clinical presentation
Steroid is usually indicated in patients with post-streptococcal glomerulonephritis (PSGN) with more than 30% crescents on renal biopsy. The role of steroids in patients without crescentic glomerulonephritis is not clear. We present a 19-year-old male patient who was diagnosed with PSGN three weeks after a sore throat infection. He developed acute renal and respiratory failure requiring. Rapidly progressive glomerulonephritis. Chronic renal failure. A combination of any of the above. The clinical presentations suggest a pathologic DDx. Isolated hematuria. IgA nephropathy. Alport syndrome. Thin glomerular basement membrane disease. Proteinuria. Diabetic nephropathy. Classic causes of nephrotic syndrome: FSGS. MCD. MN. Glomerulonefrite rapidamente progressiva (GNRP) ou glomerulonefrite crescêntica é uma doença renal caracterizada pelo declínio de mais de 50% da filtração glomerular em menos de 3 meses. Gera uma insuficiência renal aguda irreversível e potencialmente fatal. Afeta quatro em cada um milhão de habitantes, sendo mais comum entre mulheres e idosos. [ Kidneys: Goodpasture's syndrome is a rapidly progressive glomerulonephritis, while diabetic glomerulosclerosis is slowly progressive. Pancreas: Type 1 diabetes mellitus involves rapidly progressive loss of insulin secretory capacity compared to type 2 diabetes mellitus, in which the loss of insulin secretion is slowly progressive over many years
What is new in the management of rapidly progressive glomerulonephritis?. Clinical Kidney Journal. 2015-02-19, 8: sfv008. ISSN 2048-8505. PMC 4370308. PMID 25815169 Rapidly progressive glomerulonephritis did not explain the CNS symptoms, and a normal prothrombin time and activated partial thromboplastin time ruled against disseminated intravascular coagulation (5)
Common indications for use in children include steroid resistant and steroid dependent nephrotic syndrome, rapidly progressive glomerulonephritis, systemic vasculitis, systemic lupus erythematosus, acute renal allograft rejection, juvenile rheumatoid arthritis, juvenile dermatomyositis, pemphigus, optic neuritis, multiple sclerosis and acute. It can clinically emerge with a wide variety of presentations, ranging from asymptomatic microhematuria to nephrotic syndrome or rapidly progressive glomerulonephritis. It is an autoimmune disease diagnosed by immunofluorescent positive IgA mesangial deposits in the kidney biopsy  progressive disease Recommendation • Methylprednisolone pulse dosing as well as other anti-cellular immune suppressants have had limited success in rapidly progressive disease • Data are insufficient to recommend eculizumab as a first-line agent for the treatment of rapidly progressive disease. Table 5 Evaluating treatments of rapidly progressive glomerulonephritis when the response is potentially non-ignorably missing. Japanese Journal of Biometrics, 21(1):13-37. 2000. 脚注 [ 編集
Rapidly progressive glomerulonephritis (numerous crescent cells on renal biopsy). Therapy of Membranoproliferative Glomerulonephritis (MPGN) The treatment of type 1 MPGN or cases of secondary MPGN is with the treatment of the underlying cause, such as treatment of associated infection (e.g., hepatitis C) Rapidly Progressive Glomerulonephritis. RPGN is rare. It causes a marked decrease in renal function with imminent renal failure and is highly lethal. Etiologic Types. Presenting in about 10% of cases, type 1 is the rarest variant: here, antibodies agains If the initiating process is diffuse, sudden, and severe, such as in some patients with rapidly progressive glomerulonephritis (crescentic glomerulonephritis), acute or subacute renal failure may ensue with the rapid development of ESRD. In most patients, however, disease progression is more gradual and nephron adaptation is possible.. membranoosne glomerulonefriit (glomerulonephritis membranosa) Iga/IgG glomeruonefriit (glomerulonephritis mesangialis Iga/IgG) streptokokkinfektsioonile järgnev äge glomerulonefriit (glomerulonephritis streptococcalis acuta) glomerulonephritis proliferativa; pahaloomuline glomerulonefriit (ingl rapidly progressive glomerulonephritis)
La ĉi-suba teksto estas aŭtomata traduko de la artikolo Rapidly progressive glomerulonephritis article en la angla Vikipedio, farita per la sistemo GramTrans on 2017-06-03 23:35:36. Eventualaj ŝanĝoj en la angla originalo estos kaptitaj per regulaj retradukoj. Se vi volas enigi tiun artikolon en la originalan Esperanto-Vikipedion, vi povas uzi nian specialan redakt-interfacon Rapidly progressive glomerulonephritis is a syndrome of the kidney that is characterized by a rapid loss of kidney function, with glomerular crescent forma.. Rapidly progressive glomerulonephritis. Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a rapid loss of renal function, Citing: McGraw-Hill Concise Dictionary of Modern Medicine. New!!: Diffuse proliferative nephritis and Rapidly progressive glomerulonephritis · See more » Sca
Rapidly progressive glomerulonephritis, AKA crescentic glomerulonephritis (don't you just love the way that in renal medicine everything has multiple names just to make it even more complicated than it already is?!) is, as the name suggests, a particularly aggressive form of glomerulonephritis.It often presents with acute renal failure, and can progress to end stage renal failure in a matter. There are a couple different types of glomerulonephritis that fall under both categories, that's why your getting confused. Nephritic syndrome is related to Poststrep GN, Rapidly Progressive GN, and Membranoproliferative GN while Nephrotic syndrome is relate to Membranous GN Snabbt progressiv glomerulonefrit ( RPGN) är ett syndrom av njuren som kännetecknas av en snabb förlust av njurfunktion, (vanligtvis en minskning 50% i det glomerulära filtrationshastigheten (GFR) inom 3 månader) med glomerulär halvmåne bildning sett i åtminstone 50 % eller 75% av glomeruli som ses på njurbiopsier. Om den lämnas obehandlad utvecklas den snabbt till akut njursvikt och. On call and physician scheduling software for group practices, residents, hospitalists and other medical providers for call, clinic, rotation and shift schedules. OnCall Enterprise is a hospital-wide system for scheduling doctors and paging doctors on call. EasyPlot is for scientific plotting and data analysis
Membranoproliferative glomerulonephritis (MPGN) is a form of hypo-complementemic glomerulonephritis. This means that these patients generally have low serum C3 complement levels. Epidemiology. MPGN is a collection of morphologically related but pathogenically distinct disorders. As a result, true epidemologic information is difficult to come by Glomerulonephritis may be caused by problems with the body's immune system. Often, the exact cause of this condition is unknown. Damage to the glomeruli causes blood and protein to be lost in the urine. The condition may develop quickly, and kidney function is lost within weeks or months. This is called rapidly progressive glomerulonephritis Rapidly progressive (crescentic) glomerulonephritis (a form of glomerulonephritis that leads to a rapid loss of kidney function) Lupus nephritis (kidney complication of systemic lupus erythematosus) Vasculitis (inflammation of the blood vessels) Viral diseases such as mononucleosis, measles, mumps
Nephritic diseases can manifest with varying degrees of severity, ranging from asymptomatic hematuria to systemic involvement, as in rapidly progressive glomerulonephritis. The urine sediment is typically characterized by red blood cell casts , mild to moderate proteinuria ( 3.5 g/day) , and sterile pyuria Why is rapidly progressive glomerulonephritis (RPGN) caused by Wegner's or Microscopic polyangiitis considered pauci-immune? I get that in Goodpasture's you have lots of antibody against the glomerular basement membrane, so when you do immunofluorescence (IF), it lights up (excluding it from the pauci-immune category)
Chen S, Chen H, Liu Z, Zhang H, Hu W, Tang Z, et al. Pathological spectrums and renal prognosis of severe lupus patients with rapidly progressive glomerulonephritis. Rheumatol Int . 2015 Apr. 35. pauci-immune crescentic glomerulonephritis pauci-immune rapidly progressive glomerulonephritis a type of rapidly progressive glomerulonephritis in which there are epithelial crescents and antineutrophil cytoplasmic antibodies, but few, if any, immune deposits. Medical dictionary. 2011 rapidly-progressive glomerulonephritis with crescent Crescentic glomerulonephritis Great labels Romanian Pathology Atlas RPGN Crescent WebPath Photo RPGN Fibrin stain WebPath Photo This syndrome involves rapid, loss of renal function (typically loss of at least 50% of renal reserve over 3 months), usually with the nephritic syndrome. The.
Define rapidly. rapidly synonyms, rapidly pronunciation, rapidly translation, English dictionary definition of rapidly. adj. rap·id·er , rap·id·est Moving, acting, or occurring with great speed. See Synonyms at fast1 - Rapidly progressive glomerulonephritis Tubulointerstitial Diseases and Conditions - Drugs - Toxins - Infections - Multiple myeloma Acute Tubular Necrosis - Ischemia -> Shock, sepsis, severe pre-renal azotemia - Nephrotoxoins -> Antibiotics, radiographic contrast agents, myoglobinuria,.
Rapidly progressive glomerulonephritis, also termed necrotizing crescentic glomerulonephritis, is the third main manifestation of WG, noted in 40-100% of patients, depending on the series [16,27]. Neurological involvement occurs in 11-64% of cases [19,28], and is mainly represented by mononeuritis multiplex (79% of the patient التهاب كبيبات الكلى التدريجي السريع و (أختصاره:rpgn) هي متلازمة تحدث في الكلى وتسبب فقدان سريع لوظائف الكلى، (عادة انخفاض بنسبة 50٪ في معدل الترشيح الكبيبي (gfr) في غضون 3 أشهر) مع تشكيل الهلال الكبيبي بدرجة 50٪ على الأقل. Glomerulonephritis is damage to the tiny filters inside your kidneys (the glomeruli). It's often caused by your immune system attacking healthy body tissue. Glomerulonephritis does not usually cause any noticeable symptoms. It's more likely to be diagnosed when blood or urine tests are carried out for another reason Fibrillary Glomerulonephritis has been found in people between the ages of 10 and 90. It is generally found in Caucasians, although it is very difficult to predict as who may get the disease. Studies suggest that Fibrillary Glomerulonephritis is associated with disease conditions that compromise the immune system like lupus. Studies have also.
Rapidly involuting congenital hemangioma [↗] Rapidly progressive glomerulonephritis [↗] Rapid-onset dystonia-parkinsonism [↗] RAPK [↗] Rapp-Hodgkin syndrome [↗] Rare adenocarcinoma of the breast [↗] Rare adenocarcinoma of the corpus uteri [↗] Rare benign ovarian tumor [↗] Rare cervical squamous cell carcinoma [↗] Rare deafness. Glomerulonefritis rápidamente progresiva - Rapidly progressive glomerulonephritis. De Wikipedia, la enciclopedia libre. Glomerulonefritis rápidamente progresiva; Otros nombres: Glomerulonefritis creciente: Imagen histopatológica de glomerulonefritis semilunar en un paciente con glomerulonefritis rápida progresiva MPO-ANCA positivo..
The most common types of nephritic syndrome are Acute poststreptococcal glomerulonephritis, rapidly progressive (crescentic) glomerulonephritis, diffuse proliferative glomerulonephritis, IgA nephropathy (Berger disease), and Alport syndrome. Leave a comment. Post navigation. Nephrotic Syndrome and/or arthritis and glomerulonephritis. Although most symptoms are self-limiting, renal disease is the most likely to result in long-term morbidity. Epidemiology The annual incidence of IgAV in children and in- fants is estimated to be 3-26.7 per 100,000, depending ic syndrome to rapidly progressive glomerulonephritis . CRACKCast E097 - Renal Failure. In CRACKCast, Podcast by Adam ThomasAugust 3, 2017 Leave a Comment. This episode of CRACKCast covers Rosen's Chapter 97, Renal Failure. This chapter covers an approach to acute and chronic kidney injuries, including causes, complications and treatments Synonyms for Rpgn in Free Thesaurus. Antonyms for Rpgn. 2 words related to glomerulonephritis: Bright's disease, nephritis. What are synonyms for Rpgn
Glomerulonephritis, also known as Bright's disease, is a progressive kidney disease that damages the glomeruli—the filtering units of the kidney that create urine as a waste. There are two types. Wegener's Granulomatosis (recently renamed Granulomatosis with Polyangiitis) is a relatively rare form of small-vessel vasculitis classically effecting the upper respiratory tract (leading to chronic sinusitis, rhinorrhea/epistaxis, dysphonia, hearing loss, etc.), the lungs (leading to cough, chest pain, haemoptysis) and the kidneys (causing glomerulonephritis, sometimes of the rapidly. Anti-glomerular basement membrane (GBM) disease is a rare autoimmune vasculitis characterised by antibodies directed against the non collagenous (NC1) domain of the α3 chain of type 4 collagen (α3(IV)NC1). Clinical features are typically of a rapidly progressive glomerulonephritis (RPGN) with or without pulmonary haemorrhage Background Rapidly progressive glomerulonephritis (RPGN) is defined by the identification of an active urinary sediment on urinalysis, including hematuria (especially with dysmorphic red cells), red cell casts, and proteinuria (>500 mg/d) in the setting of a rising blood urea nitrogen and serum creatinine Membranoproliferative GN I (MPGN I) A kidney. Renal disease, in the form of rapidly progressive glomerulonephritis, can lead to end-stage renal disease (ESRD) requiring hemodialysis Churg-Strauss syndrome presents with necrotizing leukocytoclastic vasculitis and nodules on the extensor surfaces (shown). The nodules represent Churg-Strauss granulomas. Systemic features include asthma, cardiac vasculitis, and rapidly progressive glomerulonephritis